Inosine pranobex

Oral
Adjunct in genital warts

Oral
Subacute sclerosing panencephalitis

Oral
Mucocutaneous herpes simplex

Hypersensitivity. Gout or elevated uric acid blood levels.

Patient with history of gout or hyperuricaemia, urolithiasis. Renal impairment. Pregnancy and lactation.

Significant: Increased serum and urine uric acid, acute hypersensitivity reactions (e.g. angioedema, anaphylaxis, urticaria).
Gastrointestinal disorders: Constipation, diarrhoea, epigastric discomfort, nausea, vomiting.
General disorders and administration site conditions: Fatigue, malaise.
Musculoskeletal and connective tissue disorders: Arthralgia.
Nervous system disorders: Headache, dizziness, insomnia, nervousness, vertigo.
Renal and urinary disorders: Polyuria.
Skin and subcutaneous tissue disorders: Rash, pruritus.

Monitor uric acid levels (serum and urine) and renal function during treatment.

Increases the plasma concentration of zidovudine.

Description:
Mechanism of Action: Inosine pranobex is a purine derivative with antiviral and immunomodulatory properties. It stimulates T-lymphocyte and macrophage cell function and influences cytokine production, thereby normalising the body’s dysfunctional cell-mediated immunity.
Synonym: inosine dimepranol acedoben.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1 hour.
Metabolism: Rapidly metabolised to uric acid; also undergoes oxidation and glucuronidation.
Excretion: Via urine (as metabolites and unchanged drug). Elimination half-life: 50 minutes.

Store at or below 30°C.

Antivirals

J05AX05 - inosine pranobex ; Belongs to the class of other antivirals. Used as a direct acting antiviral in the systemic treatment of viral infections.

Anon. Inosine Pranobex. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 11/08/2020.

Buckingham R (ed). Inosine Pranobex. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/08/2020.

Imunovir 500 mg Tablets (KoRa Corporation Ltd.). MHRA. https://products.mhra.gov.uk/. Accessed 11/08/2020.

Isoprinosine (Swiss Pharma). MIMS Philippines. http://www.mims.com/philippines. Accessed 12/08/2020.

Joint Formulary Committee. Inosine Pranobex. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/08/2020.